Best Nootropics: Top 5 Smart Drugs & Brain Supplements of 2022

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Mind Lab Pro
Alpha Brain
Product Mind Lab Pro Noocube Alpha Brain
Rating ⭐⭐⭐⭐
4.50 stars
4.50 stars
4.50 stars
  • Contains 11 science-backed nootropics
  • Optimizes cognitive function
  • The third-party tested product
  • Formulated by top neuroscientists
  • Improves the ability to multitask
  • Improves the communication
  • Promotes alpha waves production
  • Improves brain’s ability to perform complex tasks
  • Third-party tested
Where to buy? Check Price Check Price Check Price

With constant distractions from digital media and cutthroat competition in our day-to-day life, it is hard to keep up with the times in this rat race. If you are a student looking for good academic grades or someone with a corporate job or even a senior citizen experiencing reduced brain power, then you are probably a candidate for a nootropic supplement. Nootropics are brain supplements that optimize brain health. 

People who are in pursuit of mental benefits such as boosting memory and memory retention should focus on getting a night of restful sleep, managing stress, and consuming nutrient-rich food. But, when that is not enough, adding a brain health supplement may boost memory.

Apart from these, taking natural nootropic ingredients could serve a great purpose to boost mental energy, improve brain health, and prevent cognitive decline due to old age. Nootropic supplements are smart drugs that can be used in attention deficit hyperactivity disorder (ADHD), dementia, and Alzheimer’s disease as they improve memory and cognitive function.

Best Nootropics on the market in (May. 2022)

  • Mind Lab Pro – Editor’s choice
  • Noocube – Best neuroscientists formula
  • Alpha Brain – Best for focus
  • Modafinil – Best performance
  • Qualia Mind – Best for a mental boost

What Is a Nootropic Stack?

Nootropics are dietary supplements that are formulated to boost brain activity and mental performance. Nootropic stacks are nothing but a combination of different nootropics for more benefits. Two or more combinations of nootropics make it a nootropic stack. Stacking nootropics can be a mix of the same type of nootropics as the mix of natural nootropics. 

The best nootropic stack supplements contain ingredients that provide cognitive benefits such as improved cognitive performance. Nootropic supplements can improve memory retention, productivity, focus, concentration, and overall brain health.  

The human brain is a complex organ and it deals with a whole heap of things on a daily basis. Our brain cells and neurons play a major role in helping our brain to keep going. But, many of us face trouble focusing for what-so-ever reasons. This is when one needs to consider the nootropics stack. They fuel our neurons and help in healthy brain function. 

If you’re wondering about how to find the right one? We conducted thorough research and came up with the best nootropic supplements for you. Read further to know about the best nootropic supplements in the market. 

Who Should Take Nootropics?

Nootropic supplements are known to boost brain capacity. They help enhance your focus and concentration and reduce brain fog. People looking for ways to boost their brain to achieve different types of goals, whether related to education or work, can use these supplements.

Mind Lab Pro-Best Nootropics
Mind Lab Pro
  • Contains 11 science-backed nootropics
  • Optimizes cognitive function
  • The third-party tested product
Noocube Best Nootropics
  • Formulated by top neuroscientists 
  • Improves the ability to multitask
  • Improves the communication
Alpha Brain Best Nootropics
Alpha Brain
  • Promotes alpha waves production
  • Improves brain’s ability to perform complex tasks
  • Third-party tested
Modafinil Best Nootropics
  • It is a prescription drug 
  • Used to treat narcolepsy
  • Enhances executive function
Qualia Mind Best Nootropics
Qualia Mind
  • Promotes slow cognitive decline
  • Can improve mental performance
  • 100-day money-back guarantee

Top 5 Best Nootropics Supplement Stacks of 2022

Mind Lab Pro

Offers a nice range of cryptocurrencies and a simple-to-use app experience. The Gemini Earn feature is also a standout perk and pays interest on idle cryptocurrencies at high rates.

  • Contains 11 scientifically proven nootropics
  • Improves mental performance 
  • Third-party testedImproves a wide range of cognitive functions
  • Only for adults over 18 years of age
  • Some ingredients have side effects

Mind Lab Pro is marketed as the first universal nootropic in the world. Mind Lab Pro was founded in 2015 and is a UK-based company. Mind Lab Pro is a dietary supplement that is designed to boost cognitive function. It is formulated with 11 science-backed nootropics that act on the four brain pathways. 

It is one of the best brain health supplements as it promotes brain health and healthy brain function such as attention, learning, memory, concentration, and focus. Mind Lab Pro contains 11 active ingredients and comes in plant-based capsules. Their formula is caffeine-free, allergen-free, gluten-free, and vegan friendly. This product doesn’t contain any artificial additives or preservatives. Mind Lab Pro is tested by third-party labs. 

It optimizes brain chemistry and improves brain health and brain function. It further improves the blood flow to the brain and regulates the brain waves. The recommended dosage for Mind Lab Pro is two capsules a day in the morning and early afternoon. You can also take them when there are intense cognitive demands, like before an exam or during an interview. You can take up to four capsules a day. However, do not take more than four capsules in a 24-hour time period.


Noocube is among the best nootropics available in the market for people with trouble focusing and memory issues such as ADHD. It can also enhance multitasking and enable better communication.

  • Formulated by neuroscientists
  • Improves communication in the brain
  • Improves mental energy and concentration
  • 30-day money-back guarantee
  • The refund policy applies only for unopened bottles
  • Expensive product

Noocube is manufactured by a UK-based company named Wolfson Brands limited.  And Noocube is formulated by some of the top neuroscientists. Noocube‘s formula is a synergistic blend of all-natural ingredients, amino acids, and vitamins in capsule form. Noocube contains a formula that’s a blend of natural Non-GMO (genetically modified organisms) ingredients such as vitamins, amino acids, and herbs that are known to improve brain function and mental performance. Noocube is a great choice for people having attention deficit issues or trouble focusing. 

Noocube greatly helps by improving memory, learning capacity, multitasking ability, and also in better communication. It enhances focus, reduces brain fog and mental fatigue, and improves mental clarity.  It reduces anxiousness and keeps your brain alert and focused. It protects the brain cells from stress-related oxidative damage. It repairs the damaged neurons and promotes new cell generation. It enhances cognitive function overall. Noocube is a caffeine-free, fast-acting formula that boosts brain function. 

The recommended dosage of Noocube is two capsules with breakfast each day. You can gradually increase the dose to 3 -4 capsules and adjust the dosage accordingly. However, they do not recommend taking more than four capsules a day. Noocube offers a 60-day money-back guarantee.

Alpha Brain

Alpha Brain is a formula that’s made to improve the alpha waves and neurotransmitters in the brain. This blend may be a great choice for people doing complex tasks and multitaskers. It boosts mental clarity and supports cognitive performance.

  • Boost production of more alpha waves
  • Helps in completion of complex tasks
  • Third-party testedProvides lasting mental clarityty of altcoin choices
  • Extremely simple user interface
  • Very high liquidity
  • Ingredients might interact with medicines
  • Expensive product

Alpha Brain is manufactured by one of the leading companies in the industry of dietary supplements. Onnit is a popular brand for selling the best nootropic supplements. It was founded in 2011 and is based out of Austin, Texas. Their products are famous among athletes and celebrities such as Joe Rogan. Their products contain ingredients that are backed by scientific research for their effect on human health. Alpha Brain has been the leader in the market of nootropics for over a decade now. 

Alpha Brain is known to support and improve the production of alpha waves and neurotransmitters in the brain. The ingredients in Alpha Brain work together in supporting healthy brain cells and an overall improvement in brain function. It improves cognitive health by enhancing memory, focus, mental processing, and performance.

It is beneficial for long-term brain health. Alpha Brain is also ideal for people doing complex tasks and people who do multiple tasks at a time. The L-tyrosine in the Alpha Brain helps in holding the peak mental performance during stressful times. Apart from this, it also helps in burning more calories. Lastly, they also offer a 90-day money-back guarantee. 


Modafinil may be a great choice for people who feel sleepy in the daytime such as shift workers and people who have odd sleeping hours. It can also be used for uncontrolled drowsiness.

  • A drug used to treat narcolepsy
  • Used in shift work sleep disorder
  • Used along with breathing devices
  • Used in uncontrolled drowsiness
  • High fees when not using Coinbase Pro
  • Reports of hacks draining users’ accounts
  • May not have as many altcoins as some other exchanges

Modafinil is a popular prescription drug that’s used to treat narcolepsy. It is commonly sold as Provigil. Modafinil falls under the class of medicines called stimulants or agents promoting wakefulness. Their mode of action is by altering the natural substances in the brain that are responsible for sleep and wakefulness. Narcolepsy is a condition where a person has daytime sleepiness. It is also used in treatments to prevent too much sleepiness due to obstructive sleep apnea. 

Modafinil is used alongside breathing devices to prevent excessive sleepiness due to obstructive sleep apnea/ hypopnea syndrome (OSAHS). OSAHS is a sleep disorder that causes the patient to stop breathing or have shallow breathing many times while they sleep and therefore doesn’t get restful sleep.

Modafinil’s[1] stimulating effects are comparable to drugs like cocaine and amphetamines. However, the risk of dependence is quite low with modafinil. Modafinil is known to reduce the feelings of mental fatigue and enhance memory in adults with sleep deprivation. Furthermore, it also improves executive functioning and time management and helps one accomplish their goals. Although modafinil is considered non-addictive, there are cases of dependence and withdrawal when taken at high doses.

Qualia mind

Qualia Mind has immediate effects on cognitive and executive function, such as memory and processing the information. It is ideal for people with cognitive decline as it targets neuroplasticity, neuroprotection, and neuron growth.

  • Enhances memory and cognition
  • 100-days money-back guarantee
  • Fuels focus and concentration
  • Suppress the appetiteolid variety of altcoin choices
  • Extremely simple user interface
  • Very high liquidity
  • Its daily dosage is seven capsules per day
  • Expensive product

Qualia Mind is a nootropic supplement that’s a complex blend of vitamins, amino acids, minerals, choline donors, antioxidants, and herbal extracts such as adaptogens. This blend of ingredients is known to help in both short-term and long-term cognitive performance.

The benefits of consuming Qualia Mind include reduced brain fog and procrastination. It lifts up the mood, promotes mental clarity, and boosts brain nutrition. It further Increases creativity, willpower, focus, and concentration. It is known to improve mental function and memory recall.

 Qualia Mind is known to target different aspects of the brain[2] that are linked to both cognitive abilities and mental performance. It targets brain chemistry, brain energy, membrane health, neuroprotection, neuroplasticity, dopamine signaling, choline signaling, and neurogenesis.  

Qualia mind tops the list of best nootropic supplements as it supports mitochondrial function, synaptic neuron formation, and acetylcholine signaling for long-term cognitive benefits. 

Qualia Mind is a blend of 28 ingredients, each of which is known to enhance memory, focus, concentration, and boost brain energy. All of them are known to slow cognitive decline and improve cognitive health. The recommended dosage of qualia mind is seven capsules a day. They also offer a 100-day money-back guarantee.

Natural Nootropics Substances For Cognitive Function


Citicoline is one of the most popular nootropic supplements in the market. Citicoline is converted into choline and uridine. Both of them are cognitive enhancers. Citicoline can increase brain chemicals such as neurotransmitters. These neurotransmitters boost mental performance and physical performance and relax muscles at the same time.

Studies[3] on models with central neurodegenerative disease have been reported to show substantial neuroprotective properties with citicoline. Citicoline treatment is reported to be beneficial in chronic neurodegenerative diseases.

Bacopa monnieri Extract 

Bacopa monnieri is a popular ancient herb widely used in Ayurveda to boost brain power and enhance brain function. Studies[4] have found that Bacopa monnieri supplements improve the mental processing speed in the brain, improve memory and reduce reaction times. Bacopa monnieri contains active ingredients called bacosides that protect are known to protect the brain from oxidative stress. It further improves the signaling in the hippocampus. The hippocampus[5] is part of the brain where our memories are processed.


Caffeine is a popularly consumed psychoactive substance. Most people consume coffee as it keeps them sane. Caffeine can block the brain signaling molecules by blocking the adenosine receptors[6] in our brain, making us feel energetic. This causes an increase in other signaling molecules such as norepinephrine and dopamine. Caffeine can elevate mood, reduce depression, boost brain function and protect against Parkinson’s disease and Alzheimer’s disease.

Rhodiola rosea 

Rhodiola rosea is a herb that has adaptogenic properties. Adaptogens help our body adapt to periods of high stress efficiently. It further helps by reducing mental fatigue. The adaptogenic properties of Rhodiola make it to the top of this list of popular nootropic supplements as it reduces depression and stress levels and can influence the neurotransmitters in the brain that are associated with emotion and mood. 

Several studies[7] reported that Rhodiola rosea dietary supplements could elevate mood and reduce the feelings of burnout in individuals with anxiety and stress. Further health benefits of Rhodiola rosea include improved physical performance and managing diabetes. 


Phosphatidylserine[8] is a phospholipid that is essential for the proper function of nerve cells in the brain. It helps in transmitting messages between them. These supplements were made at one time from the cow brain. However, these days they are made from cabbage or soy. 

Phosphatidylserine is commonly used for Alzheimer’s disease, attention deficit hyperactivity disorder, and age-related cognitive decline. 

Benefits of Using Brain Pills

Lowers Stress Levels 

Nootropics are brain pills that are known to reduce stress. Nootropic drugs work by stimulating the production of brain neurotransmitters such as dopamine and serotonin through the process called “agonist-activator” pharmacology[9]. These hormones are also known as feel-good hormones and happy hormones. Nootropics make one feel happier and more relaxed. This, in turn results in improved cognitive performance.  

They Promote Restful Sleep 

The deleterious effects of long-term sleep deprivation put one’s health at stake. It can make one jittery, anxious, lose focus, and be inattentive. It can further lead to short-term memory retention and serious effects on overall health.

 Nootropics promote calmness and sleep. Tyrosine is known to reduce anxiety and relieve stress and promote sleep. Whereas modafinil is popularly used as a selective wakefulness-promoting agent[10] in sleep-deprived individuals. Modafinil is known to improve cognitive function in sleep-deprived individuals. 

They Can Improve Memory 

Nootropics are known to improve memory by improving the body’s cells through amino acids[11] that support neurons in transmitting signals quickly. Bacopa monnieri is known to improve short-term memory. It is also known to improve the signaling between the hippocampus. Hippocampus is associated with storing memories in the brain and also plays a vital role in memory recall. 

Aids in Balancing Mood 

Anxiety and mood swings are part and parcel of the hurry-scurry life. It can affect memory, mood, and how we perform. Nootropic supplements can have effects on these issues. L- Theanine is known to increase alpha brain waves; these waves promote relaxation and alertness. L-theanine is popularly used as a cognitive enhancer to reduce tension and anxiety. Whereas L-tyrosine[12] is an amino acid that helps in the production of dopamine, adrenaline, and norepinephrine

They Can Boost Focus 

We have all experienced brain fog after a long tiring day at work. Nootropics can support our brain by focusing on a single task while ignoring external stimuli. Nootropics can help you in staying focused and improve your performance as well as promote relaxation.

They Can Boost Mental Energy 

Nootropics are known to boost energy in the brain and can help mental acuity. Ginkgo biloba is known to increase the blood flow to the brain by increasing mental energy. Ginkgo biloba supplements have been reported to improve mental processing[13] and memory.

Potential Side Effects

Nootropics are also known as “smart drugs” or “brain pills,” which are nothing but stimulants. Consuming nootropics in the long term can have adverse effects.  Side effects may occur, such as insomnia, high blood pressure, blurry vision, fast heart rate, addiction, and circulation problems. 

These side effects may lead to more serious problems like high blood pressure due to insomnia; the raised heart rate could lead to circulation issues. And one of the common side effects among teenagers is addiction. Unmanaged dosing of nootropics can lead to addiction. Lastly, nootropics are known to cause drug interactions. Hence, it is always best to consult a doctor if you are on medications.

How To Take Nootropics?

Nootropics are available on the market in three different forms such as dietary supplements, prescription drugs, and synthetic drugs. They are sold in the form of gummies, capsules, or powders. So, taking nootropics will depend on their form. However, most nootropic dietary supplements come with detailed instructions on how and when to consume them. 

However, it is best to talk to a health professional to know the ideal dosage to take. Ideally, one should take nootropics in the morning or the evening so that you are benefited from a productive day or a good restful sleep, depending on the nootropic being ingested. 

Final Thought

Nootropics and smart drugs are the best supplements to boost brain capacity and for cognitive benefits. You can manage stress, relax and get good sleep with these smart drugs. If you are someone looking for a boost in mental capacities such as memory, focus, concentration, and cognitive function. However, it is wise to consult medical experts to find the right dosage for you.

Frequently Asked Questions (FAQs)

How much does a nootropic cost?

On average, nootropic supplements cost around $50 to $70 per month. Nootropics are formulated with extensive research, and you are not just paying for the brain pill; you are also paying for the hard work that went with it making that formula.

Are nootropics FDA approved?

On average, nootropic supplements cost around $50 to $70 per month. Nootropics are formulated with extensive research, and you are not just paying for the brain pill; you are also paying for the hard work that went with it making that formula.

Can smart pills help with ADHD?

Yes, nootropics can be an excellent alternative to traditional ADHD medication.

+ 8 sources

MIDSS has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. We work mostly with peer-reviewed studies to ensure accurate information. We avoid using tertiary references. You can learn more about how we ensure our content is accurate and current by reading our editorial policy.

  1. Krishna Rao, R. (2012). Role of Glutamine in Protection of Intestinal Epithelial Tight Junctions. Journal of Epithelial Biology and Pharmacology, [online] 5(1), pp.47–54. Available from: [Accessed 24 Mar. 2021].
  2. ‌Suzuki, T. & Hara, H. (2009). Quercetin Enhances Intestinal Barrier Function through the Assembly of Zonnula Occludens-2, Occludin, and Claudin-1 and the Expression of Claudin-4 in Caco-2 Cells. The Journal of Nutrition, [online] 139(5), pp.965–974. Available from:
  3. ‌Gustafson, C. (2016). Amie Skilton, nd, bhsc: Inflammation in the Gut Drives Systemic Inflammation. Integrative medicine (Encinitas, Calif.), [online] 15(4), pp.32–4. Available from:‌/
  4. Sicard, J.-F., Vogeleer, P., Le Bihan, G., Rodriguez Olivera, Y., Beaudry, F., Jacques, M. & Harel, J. (2018). N-Acetyl-glucosamine influences the biofilm formation of Escherichia coli. Gut Pathogens, [online] 10(1). Available from:
  5. Peterson, C.T., Sharma, V., Uchitel, S., Denniston, K., Chopra, D., Mills, P.J. & Peterson, S.N. (2018). Prebiotic Potential of Herbal Medicines Used in Digestive Health and Disease. The Journal of Alternative and Complementary Medicine, [online] 24(7), pp.656–665. Available from:
  6. Foster, M., Hunter, D. & Samir Samman (2011). Evaluation of the Nutritional & Metabolic Effects of Aloe vera. [online] Available from:
  7. Lull, C., Wichers, H.J. & Savelkoul, H.F.J. (2005). Antiinflammatory and Immunomodulating Properties of Fungal Metabolites. Mediators of Inflammation, [online] 2005(2), pp.63–80. Available from:
  8. Skrovanek, S. (2014). Zinc and gastrointestinal disease. World Journal of Gastrointestinal Pathophysiology, [online] 5(4), p.496. Available at:‌


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Welcome to the Measurement Instrument Database for the Social Sciences (MIDSS). The site is designed to be a repository for instruments that are used to collect data from across the social sciences. Please use the site to discover instruments you can use in you own research.