Best CoQ10 Supplement 2023: Our Top 5 Picks

Reviewed by Dr. Drew Sutton, MD

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best coq10 supplement

Coenzyme Q10 (CoQ10) is found in nearly every cell of the human body. It is essential for cellular energy production as well as protecting them from oxidative stress. CoQ10 has recently gained popularity as a potential supplement for a variety of health conditions. This review will help you decide on the best coenzyme Q10 supplements.

Coenzyme Q10 is a fat-soluble compound[1] found in all human body cells. The compound, also known as ubiquinone, aids in the production of energy in the mitochondria, the cell’s energy source. CoQ10 is essential in the electron transport chain, which generates adenosine triphosphate (ATP), the body’s primary energy source. CoQ10 supplements are marketed to athletes as having the ability to improve exercise performance and reduce fatigue. Many studies published in reputable journals show that supplementing with CoQ10 improves endurance, exercise performance and reduces muscle damage, particularly in trained male runners. Others come to the conclusion that the supplement improves maximal power output and total work capacity during high-intensity exercise. In this review, we look into the specifics of CoQ10 supplements and compare the features and benefits of various CoQ10 supplements, backed up by evidence from users all over the world.

Best CoQ10 Supplements 2023

Feature of Product

CoQ10 is lipid soluble but water insoluble. Because the compound is fat-soluble, it requires fat to be absorbed and transported throughout the body. It is essential for cell energy production, particularly in the electron transport chain that generates adenosine triphosphate. ATP provides the energy required for various metabolic processes. Coenzyme Q10 also aids in the prevention of oxidation, shielding cells from the oxidative damage caused by free radicals.[2] It is found in a variety of foods, including meat, fish, nuts, and seeds. However, getting enough through diet alone can be difficult. Its supplements are widely regarded as safe and well-tolerated. Some, however, have a few side effects.

Best CoQ10 Supplement 2023

Transparent Labs CoQ10

Transparent Labs is committed to transparency, providing products with few ingredients and at reasonable prices. Transparent Labs is a good option if you want a reliable brand that sells genuine supplements.

  • High-quality ingredients
  • Does not cause stomach irritation
  • Wide variety of products
  • Does not indicate founders’ information
  • Limited flavors

“The flavors aren’t fantastic, but they’re bearable. The flavors are strong so I always add extra water. The beta alanine tingles are very strong. Makes my ears and forehead itchy. Gets me a good workout and good results. It is nice that their labels are “transparent” so you know what you’re putting in your body. Will continue to buy.”

Jared B

“Started with the full one scoop 30 minutes before workout. Slight skin tingles in 5 min. Noticed increase in blood vessel dilation. You can push harder during lifts.”


“The first and only orange flavored supplement that actually tastes like orange juice. It reminds me of Tropicana. Just the right amount of ingredients and delivers as promised.”

Amazon Customer

“The first and only orange flavored supplement that actually tastes like orange juice. It reminds me of Tropicana. Just the right amount of ingredients and delivers as promised.”

Amazon Customer

Life Extension Super-Absorbable CoQ10 (Ubiquinone) With D-Limonene

In comparison to other brands, Life Extension Super-Absorbable CoQ10 is more expensive. On the other hand, for the price, you get more capsules.

  • Gluten Free
  • Non-GMO
  • 30-day returns
  • May need physician guide
  • Relatively expensive

“This product worked well for me. All of my lab numbers were fabulous. Best A1C cholesterol in years.”

Terri Williams

“Will only use this product.”

Milione N.

“Have tried many different kinds over the years and this one is the best because of the d limonene. The d limonene helps greatly with absorption allowing the coq10 to penetrate the cells and help the mitochondria based on what I read. Coq10 comes in crystalized and non crystalized forms and the non crystalized is the best based on my research due to better absorption into the cells. The d limonene is the key by breaking the coq10 into smaller particles and helping to deliver the nutrient. Also Dr Sinatra recommends ubiquinone over the more expensive ubiquinol (more expensive but not more effective).”

Amazon customer

“Great product for the money as well as easy to use and helped me with frequent heart palpitations.”


“Originally this was delivered Monday to another address, and the neighbor brought it to me yesterday.”

Margaret Borsi

Mary Ruth’s CoQ10 Gummies

Mary Ruth’s CoQ10 Gummies have a delicious flavor. The gummies, on the other hand, are sticky and easily damaged by heat.

  • Great taste
  • No animal source gelatin
  • No colorants or preservatives
  • Lacks quality control
  • Gummies stick together

“I normally hate gummies. I have a hard time with that kind of texture. But I love these! Great flavor and it doesn’t stay in my mouth for a while like other gummies.”

Amazon Customer

“First of all they’re delicious but second they give me a boost in energy. I’ve taken them in the afternoon at times when I’m feeling fatigued and they boost me right up. Love Mary Ruth’s, pretty much the only brand of vitamins I have for my family.”

Deanna White

“They get a little sticky, but taste good and are easier to chew and eat like candy rather than trying to swallow a large pill!”

Marcia C. Maytner

“The CoQ10 from Mary Ruth is a great tasting chewy vitamin! I like the fact that it has more natural ingredients compared to some of the other brands I have found. We have purchased this product several times!”

Lisa S

“My daughters Neurologist told me to get these for her…they are now MY favorite treat. I don’t even know what this vitamin is good for LOL but I take it religiously. And yes, she loves them too.”


Live Conscious CoQWell

Live Conscious CoQWell is one of the most effective CoQ10 supplements. It is highly recommended for use because of the great results, and numerous positive reviews back up its effectiveness.

  • Gluten free
  • Support heart health
  • Highly bioavailable
  • My cause sleeplessness
  • Unexpected side effects

“After taking it for a few months I will know if it helped lower my cholesterol. Its easy to swallow, no after taste.”

Lisa Rico

“This product has all the ingredients in amounts specifically needed and at the best price.”

Karen Doval

“It’s like taking speed! Can’t sleep even after 12 hours; 18 hours.. had to take a Xanax!!”


“I have been using this product for several years with good results based on annual bloodwork. I am writing now to say the most recent bottle delivered had capsules that appear to have melted together. I am unable to get the capsules out of the bottle! I do not know how this happened as I keep my bottles in a drawer in the bathroom. I do not know why this happened but will be checking my next order as soon as it arrives.”

J. Obrien

Garden of Life Raw CoQ10

Garden of Life Raw CoQ10 is a potent supplement that delivers on all of its promises. It is recommended for everyone, though it may cause some side effects such as diarrhea and nausea.

  • GMO Free
  • Vegan friendly
  • 30-day returns
  • May have side effects
  • Relatively expensive

“This is a quality item with quality service. I am concerned about highly increased price.”

Amazon Customer

“This has made a huge difference in my fibromyalgia, especially the flares. It has also helped my husband with his PMR. I swear by this stuff!”


“Everyone could use this product. I could defiantly tell when I used it and would continue to use because of all the positives like hair is better skin is better Just more positive all the way.”

Landmark Janette

“I was actually told to get on coq10 when I went into pre-Menopause my doctor told me that woman’s hormones are stripped during that time and this would help. not only is coq10 good for joints but it has totally relaxed me and kept me from jail. 😉🤣 anyways I’m hooked and will never get off.”

Caney Creek

“I have been taking this product for a couple of years now for Blood Pressure especially, and overall well being. Excellent product! It seems to address small things that I didn’t even know was a problem like knee pain and such. I would highly recommend it!”


What Is CoQ10?

Coenzyme Q10 (CoQ10) is a vitamin-like compound[3] found in the body that can be obtained through a variety of dietary supplements. The compound is essential in cellular energy production, particularly in the production of adenosine triphosphate. It is essential in the body because Adenosine triphosphate (ATP) is the primary energy source for cellular processes.

CoQ10 is an extremely potent antioxidant. It aids in the protection of cells against oxidative damage caused by free radicals. It is abundant in high-energy-demanding organs such as the heart, liver, and kidneys, and its levels tend to decline with age.

How Do CoQ10 Supplements Work?

Supplemental coenzyme Q10 (CoQ10) gives the body access to additional amounts of this crucial molecule, which is involved in antioxidant activity and energy production. They support cardiovascular[4] health, oxidative damage prevention, and cellular energy production.

The supplements have a number of advantages and can be used to treat a number of illnesses, such as migraines, high blood pressure, congestive heart failure, boosting the immune system, lower blood sugar and treating complications in the cardiovascular system. There is still much to learn about the precise mechanisms of action. Nevertheless, CoQ10 may enhance cardiovascular health by lowering oxidative stress, enhancing endothelial function, and reducing inflammation.

Benefits Of CoQ10 Supplements

The following are some of the main advantages of CoQ10 supplements:

  • Supporting heart health: CoQ10 is crucial for the heart’s healthy operation. Numerous studies show that taking supplements can reduce inflammation, lower blood pressure, and enhance the heart’s capacity to pump blood.
  • Reduces muscle damage- CoQ10 can aid in reducing fatigue and muscle damage caused by exercise. Because of this benefit, its supplements are well-liked by athletes.
  • Supporting migraine prevention or treatment: CoQ10 reduces the risk of migraines. By primarily reducing inflammation, they aid in lowering both the frequency and severity of headaches.
  • Enhancing cognitive function: CoQ10 may aid in preventing oxidative brain damage and enhancing cognitive function, particularly in the elderly.
  • Enhancing fertility: CoQ10 improves the quality and movement of sperm.[5] Men’s fertility and women’s egg quality may both benefit from supplementation.

When Should CoQ10 Be Taken?

When to take Coenzyme Q10 (CoQ10) supplements depends on the individual and the reason for consumption. When it comes to general health, supplements can be taken at any time of day. Some people prefer to take supplements in the morning to increase their energy levels. Others prefer to take the supplements at night to avoid side effects, particularly stomach upset.

How To Choose The Best CoQ10 Supplements

Choosing the best Coenzyme Q10 (CoQ10) supplement can be difficult because there are so many different brands and formulations available. However, if several factors are taken into account, good supplements can be obtained. When selecting a CoQ10, the following factors should be taken into account:

  • Quality- Select a supplement from a reputable manufacturer who employs proper manufacturing practices to ensure the product meets stringent quality standards.
  • CoQ10 is available in two formulations: ubiquinone and ubiquinol. The former is in oxidized form, whereas the latter is reduced. One should consider ubiquinol supplements because it has superior absorption compared to ubiquinone.
  • Dosage- Choosing a supplement with a dosage that corresponds to your health concerns is critical. However, the recommended daily dose of CoQ10 for general wellness ranges from 50 to 300 mg.
  • Price- CoQ10 supplements vary in price. When making a purchase, keeping your budget in mind is critical. It is also worth noting that more expensive supplements may not be superior to less expensive alternatives.
  • Ingredients- Read the ingredient list to learn about the composition of the supplements. The recommended products have no fillers, artificial colors, and preservatives.
  • Bioavailability-This metric determines how effective a supplement is at providing the desired health benefits. Choose a supplement with high bioavailability to maximize the amount of the compound available for use in the body.

Final Thought

CoQ10 is essential for energy production within cells. Although it is naturally occurring, supplementation may help increase its presence and functionality in the body. It can help boost cardiovascular health, oral and gum health, protect cells from damage, and lower the risk of chronic diseases.

Choosing the best CoQ10 supplement necessitates careful consideration of a number of variables. It is best to seek out a high-quality product made by a reputable manufacturer. It’s also important to look for third-party certification and make sure the supplement contains enough CoQ10 to help you reach your health goals.

Frequently Asked Questions (FAQs)

What Is CoQ10?

CoQ10 (Coenzyme Q10) is a naturally occurring compound in all human cells. 

What Is the importance of CoQ10?

Coenzyme Q10 promotes energy production within cells. It supports the production of ATP, which is the main energy source. 

When should I take CoQ10 supplements?

The best time to take CoQ10 varies depending on individual health needs and goals. Some individuals favor taking supplements in the morning to boost their energy levels. Others choose to take supplements at night to avoid side effects. 

How should I take CoQ10 supplements?

It is recommended that one takes CoQ10 with a meal that has fats to improve absorption.

What is the right dosage of CoQ10 supplements?

Dosage varies depending on individual health needs and goals. However, the recommended daily dose of CoQ10 ranges from 50 to 300 mg.

How should I choose CoQ10 supplements?

Consider the supplement that best meets the basic criteria, such as quality, formulation, dosage, price, ingredients, and bioavailability.

Can CoQ10 affect other medications?

CoQ10 supplements can impair the effectiveness of some medicines especially statin medications, blood thinners and blood pressure medications. If you are on medication, you should consult a professional healthcare provider before taking CoQ10 supplements.

Are CoQ10 supplements safe?

CoQ10 supplements are generally regarded as safe if taken in the recommended doses. Some people, however, may experience some minor side effects, particularly nausea and stomach upsets.

+ 5 sources

MIDSS adheres to strict procurement guidelines and relies on peer-reviewed studies, academic research institutes, and medical associations. We work mainly with peer-reviewed studies to ensure the accuracy of the information. We avoid the use of tertiary references. You can read about how we ensure the accuracy and timeliness of our content in our editorial process.

  1. National Cancer Institute. (2022). Coenzyme Q10 (PDQ®)–Health Professional Version. [online] Available at:
  2. Pallotti, F., Bergamini, C., Lamperti, C. and Fato, R. (2021). The Roles of Coenzyme Q in Disease: Direct and Indirect Involvement in Cellular Functions. International Journal of Molecular Sciences, [online] 23(1), p.128. Available at:
  3. NCCIH. (2017). Coenzyme Q10. [online] Available at:
  4. Zozina, V.I., Covantev, S., Goroshko, O.A., Krasnykh, L.M. and Kukes, V.G. (2018). Coenzyme Q10 in Cardiovascular and Metabolic Diseases: Current State of the Problem. Current Cardiology Reviews, [online] 14(3), pp.164–174. Available at:
  5. Alahmar, A.T. (2019). The impact of two doses of coenzyme Q10 on semen parameters and antioxidant status in men with idiopathic oligoasthenoteratozoospermia. Clinical and Experimental Reproductive Medicine, [online] 46(3), pp.112–118. Available at:


Teresa Mboci
Pediatric Nurse, Nutritionist, and Wellness Author
A dedicated pediatric nurse with a passion for nutrition and wellness, Teresa has made it her mission to empower families with the tools and knowledge they need to promote optimal health and well-being in their children. With over 8 years of experience in the healthcare field and a background in nutrition, Teresa brings a unique perspective to the challenges facing families today. In her role as a pediatric nurse, Teresa has seen firsthand the impact that diet and lifestyle can have on a child's health, and in her writing, she shares her expertise and insights with a broader audience. Whether through her books, articles, or speaking engagements, Teresa is committed to helping families navigate the complexities of pediatric health and wellness with confidence and compassion.


Drew is a retired ENT doctor who now lives in the Southeastern US. He was a member of the American Academy of Otolaryngology and a Fellow of the American College of Surgeons. He has a bachelor’s degree in Biology and Psychology and an MD degree. He completed his internship in General Surgery and Residency in Otolaryngology-Head and Neck Surgery and practiced for almost 30 years in all aspects of ENT, including a specialization in disorders of the ear and skull base. Drew is passionate about communicating his clinical experiences and making his knowledge more accessible to the general public by medical writing.

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