Best CBD Oil For Pain & Inflammation: Top 9 CBD Brands 2023

Reviewed by Dr. Drew Sutton, MD

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best cbd oil for pain

Cannabidiol, or CBD, is prevalently becoming the most sought natural remedy for pain management. CBD is derived from the cannabis plant and is used to make pain-relieving products without psychoactive effects. Unlike most pain relief remedies, such as opioids and other prescription medications, CBD oil has little to no side effects. Hemp-derived CBD products come in various forms, including CBD oil tinctures, gummies, capsules, topicals, and many more.

CBD products also contain different types of CBD oil, including full spectrum, broad spectrum, and CBD isolate. Full spectrum CBD oil contains all the chemical compounds in a hemp plant, including THC, offering the “entourage” effect. Broad spectrum has all the compounds in a cannabis plant except the THC, while CBD isolate contains pure CBD.Since there are various reasons[1] why people prefer using CBD products, the CBD industry is flooded with numerous CBD companies claiming to design the best products. This article lists and describes some of the best CBD oil companies in 2022 that offer top-notch CBD products with effective pain-relieving benefits.

Best CBD Oil for Pain: 9 Top Picks To Be Pain-Free In 2023

The following is the list and description of the best CBD companies that are reputable for designing premium CBD products. 

Best CBD Oil For Pain & Inflammation: Top 9 Brands Of 2023


CBDfx Oil

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This brand is known for offering vegan CBD oil. This is among the best CBD oils that are third-party tested and contains Non-GMO ingredients.

  • Vegan friendly
  • Full spectrum CBD oil
  • Non-GMO
  • Third-party tested
  • Expensive
  • Contains THC

This full-spectrum CBD oil is an excellent option for pain relief. It comes in multiple potencies that range from 500mg to 4000 mg of CBD oil. This vegan-friendly CBD oil for pain management is an excellent option if you seek to experience the “entourage” effect. If you want to avoid THC, this CBD oil is not an excellent option.

Joy Organics


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This CBD company has a solid reputation for offering third-party tested CBD products that contain USDA-certified organic CBD oil.

  • Third-party tested
  • USDA certified organic
  • Multiple flavors and potencies
  • Comes with a 90-day money-back guarantee
  • Relatively pricey

This company offers premium full-spectrum and broad-spectrum CBD oils. All CBD products undergo third-party testing to guarantee efficacy, purity, and potency. This CBD brand also offers multiple flavors, including  Fresh lime, Tropical sunrise, Summer lemon, Orange bliss, Strawberry and Champagne, and Tranquil mint. These broad-spectrum and full-spectrum CBD oils come with a 90-day money-back guarantee. This brand offers some of the best CBD oils for chronic pain and other health benefits.

Spruce CBD

Spruce CBD Oil

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This family-owned company offers top-tier quality pain relief CBD products. These products contain full-spectrum CBD oil and undergo rigorous third-party testing.

  • Full spectrum CBD oil
  • Third-party laboratory testing
  • High potencies
  • Has no flavor options

Spruce offers some of the best CBD oils to manage pain. You can alleviate chronic pain in the muscles, joints, back, and many more by using this full-spectrum CBD oil. These CBD products come in high potencies ranging from 25 to 80 mg. The brand also offers a 30-day money-back guarantee.

 Savage CBD

Savage CBD

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This company offers affordable CBD products that come in multiple potencies and flavors. These CBD products are third-party tested and contain full-spectrum CBD oil.

  • Third-party tested
  • Multiple potencies
  • Multiple flavors
  • Moderately priced
  • No return policy

Savage CBD offers a vast selection of CBD oil for pain. These products come in multiple flavors, including cucumber mint, pink grapefruit, peach pear, and lemon-lime. They also come in multiple high potencies that range from 1000mg to 2000mg of CBD oil. They contain full-spectrum CBD extract that contains less than 0.3% of THC.

 Royal CBD


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This brand has a solid reputation for providing premium CBD oil for pain. The brand stocks third-party tested CBD products that come in multiple potencies and flavors.

  • Multiple flavors
  • Multiple potencies
  • Third-party tested
  • Uses CO2 method of extraction
  • Expensive
  • Contains THC

Royal CBD offers full-spectrum CBD oil for chronic pain. The products come in multiple potencies ranging from 500mg to  2500 mg CBD oil and various flavors, including natural, vanilla, mint, berry, and earthy. These products are third-party tested and come with a 30-day money-back guarantee. You can experience immense chronic pain relief by taking CBD oil from this company.


CBDPure Oil

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This CBD brand has a solid reputation for offering premium CBD oil for pain, anxiety, PTSD, and other health conditions.

  • Moderately priced
  • Third-party tested
  • Offers a 90-day money-back guarantee
  • Uses CO2 method of extraction
  • Full-spectrum
  • There are no flavor options
  • Limited production options

This CBD oil for pain management comes in multiple potencies that range from 300mg to 1000mg. This full-spectrum hemp oil undergoes third-party testing to guarantee potency, quality, and purity. This CBD oil for pain is an excellent option for anyone seeking to experience the “entourage” effect of the beneficial compounds from a cannabis plant.



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This brand offers some of the most reasonably priced CBD-infused products. This company offers multiple spectrums, including pure CBD, broad spectrum, and full spectrum. 

  • Moderately priced
  • Approved by the US Hemp Authority
  • THC-free option
  • Third-party tested
  • No multiple flavors options

This CBD oil for pain comes in different types. The brand offers CBD isolate, full spectrum, and broad spectrum CBD oil. These products have a solid reputation for alleviating various health conditions, such as chronic pain and anxiety. This CBD oil for pain management is third-party tested, and all the results are available on the brand’s official website.

Nuleaf Naturals

NuLeaf Full Spectrum Hemp CBD Oil

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This CBD oil for pain relief comes with free shipping and undergoes third-party testing.

  • Uses hemp grown in the USA
  • Third-party lab tested
  • Free shipping
  • Used the C02 method of extraction
  • No multiple strengths

This CBD oil can alleviate chronic pain, inflammation, anxiety, and many more. The brand offers a full spectrum that contains all the beneficial cannabinoids in a hemp plant, including CBD, CBC, CBN[2], and CBG. Each product comes with a 30-day money-back guarantee and is third-party tested for strength, efficacy, and purity.


Medterra CBD Oil

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This brand offers a vast range of CBD products with multiple flavors, spectrums, and potencies.

  • Third-party tested
  • Has THC-free options
  • Multiple potencies
  • Approved by US Hemp Authority
  • Restrictive return policy

This company is an excellent option if you seek CBD oil for chronic pain. It comes in multiple potencies ranging from 500mg to 6000mg. The product has multiple flavors, such as citrus, chocolate mint, and strawberry mint. You can choose from full-spectrum, CBD isolate, and broad-spectrum CBD oil. The company offers a 30-day money-back guarantee; therefore, you can return the order in case of unsatisfactory results.

What Does Research Say

Studies show CBD oil can address various health conditions such as chronic pain, anxiety, inflammation, seizures, and many more. Epidiolex is the first CBD-infused drug with FDA approval to deal with seizures associated with  Lennox-Gastaut syndrome (LGS) and Dravet syndrome. There are animal-based researches that suggest cannabidiol offers the following health benefits:

What Is CBD Oil?

CBD is among the numerous chemical compounds in hemp plants. Studies[6] show that cannabidiol offers various therapeutic health benefits. Numerous cannabinoids, including terpenes, flavonoids, THC, and many more, are present in cannabis. This is a substance that cannabinoids were used to make. It is often diluted with hemp seed or coconut oil and is not psychoactive. Many people use CBD to treat various physical and mental health issues. The main psychoactive substance that produces a “high” experience is THC. Contrarily, CBD has become one of the most well-liked all-natural treatments for easing pain and lowering tension.

How Does It Work?

CBD oil can offer pain management by interacting with the endocannabinoid system[7] (ECS). CBD[8] stimulates the  CB1 and CB2 receptors in the  endocannabinoid system. CB1 receptors are especially found in the brain and are responsible for controlling memories, appetite, thinking, mood, emotion, pain, movement, and many more. On the other hand, CB2 receptors are especially found in the immune system and affect pain and inflammation.

How CBD Oil Helps Relieve Pain?

CBD-infused products are a natural alternative for addressing chronic pain. CBD can relieve joint, back, and muscle pain as it contains anti-inflammatory properties. By stimulating the ECS, CBD oil for pain can alleviate pain and inflammation in the body. It binds the CB1 and CB2 receptors in the brain and immune system. Through this, CBD oil for pain management aids the body in modulating pain signals and producing inflammatory cytokines.

How Long Does It Take For CBD Oil To Work For Pain?

It might take fifteen to forty-five minutes; however, this duration relies on various factors, including:

  • Form of CBD consumption, i.e., tinctures, gummies, sprays, topicals, and many more
  • CBD concentration
  • CBD dosage
  • Your body type
  • Food intake
  • Frequency of CBD consumption

How To Choose The Best CBD Oil For Pain

If you are seeking to purchase CBD-infused products, consider the following factors:

  • Third-party testing
  • Source of CBD oil
  • Carrier oil, i.e., MCT oil, coconut oil, vegetable oil, and many more
  • CBD oil flavors
  • Customer feedback
  • Brand reputation
  • COA accessibility

Health Benefits Of CBD Oil

Taking CBD-infused products can offer the following health benefits[9]:

  • Relieving pain
  • Improving sleep quality
  • Boosting mental health by reducing PTSD, anxiety, depression, and stress symptoms
  • Alleviating pain related to cancer
  • Reducing seizures[10]
  • Alleviating inflammation[11]
  • Combating drug addiction[12]
  • Boosting skin health[13]

Potential Side Effects

CBD-infused products can result in various side effects[14], including:

  • Impotence in men
  • Mood swings
  • Negatively interaction with other drugs
  • Loss of appetite
  • Weight changes
  • Drowsiness
  • Nausea

Nursing and pregnant women[15] should avoid these products. People with an underlying condition or any prescribed medication should consult a healthcare provider before using these products.


CBD oils can be consumed in various forms, and there is no standard dosage. However, if a healthcare provider medically prescribes it for controlling seizures associated with epilepsy, adhere to the recommended dosage. The proper dosage relies on various factors such as:

  • Form of CBD consumption, i.e., cbd topical cream, tinctures, gummies, sprays, and many more
  • CBD concentration
  • Desired result
  • Your body type
  • Food intake
  • Targeted health condition

Final Thought

CBD-infused products are an excellent natural alternative for internal and localized pain relief. You can also use them for relieving anxiety, depression, and inflammation, improving sleep quality, reducing seizures, and many more. Nursing and pregnant women should avoid these products. People with an underlying condition or any prescribed medication should consult a healthcare provider before using these products.

Frequently Asked Questions (FAQs)

Is buying CBD legal?

You can purchase CBD oil, so long as it contains the legal limit of THC, 0.3%. However, CBD is illegal in some states.

Will I get high?

No. These products do not have psychoactive properties.

How long till I see results?

This depends on the method of administration. Vaping and smoking offer immediate results compared to edibles, capsules, and topicals.

What other health benefits does CBD oil offer?

Apart from relieving anxiety, these products can help reduce pain, boost brain functionality, prevent neurological diseases, manage chronic pain, and many more.

Are there any side effects?

Some users report various side effects[16], including diarrhea, agitation, appetite change, drowsiness, and irritability.

What is the best CBD brand?

There are many brands offering premium quality products. The ones mentioned above are among them.

What is the age limit for using CBD?

This differs from one state to another; however, you should be at least 18-21 years or older.

Are there pain CBD-infused products for pets?

Yes, these companies offer CBD pet treats and oils to relieve anxiety for pets.

+ 16 sources

MIDSS adheres to strict procurement guidelines and relies on peer-reviewed studies, academic research institutes, and medical associations. We work mainly with peer-reviewed studies to ensure the accuracy of the information. We avoid the use of tertiary references. You can read about how we ensure the accuracy and timeliness of our content in our editorial process.

  1. (2018). CANNABIDIOL (CBD): Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews. [online] Available at:
  2. Russo, E.B. and Marcu, J. (2017). Cannabis Pharmacology: The Usual Suspects and a Few Promising Leads. Cannabinoid Pharmacology, 80, pp.67–134. doi:10.1016/bs.apha.2017.03.004.
  3. Harvard Health. (2011). Pain, anxiety, and depression – Harvard Health. [online] Available at:
  4. Shafik Boyaji, MD (2020). CBD for chronic pain: The science doesn’t match the marketing – Harvard Health. [online] Harvard Health. Available at:
  5. Harvard Health. (2007). Exercise: Rx for overcoming osteoarthritis – Harvard Health. [online] Available at: .
  6. Rapin, L., Gamaoun, R., El Hage, C., Arboleda, M.F. and Prosk, E. (2021). Cannabidiol use and effectiveness: real-world evidence from a Canadian medical cannabis clinic. Journal of Cannabis Research, [online] 3(1). doi:10.1186/s42238-021-00078-w.
  7. Lu, H.-C. and Mackie, K. (2016). An Introduction to the Endogenous Cannabinoid System. Biological Psychiatry, [online] 79(7), pp.516–525. doi:10.1016/j.biopsych.2015.07.028.
  8. Zou, S. and Kumar, U. (2018). Cannabinoid Receptors and the Endocannabinoid System: Signaling and Function in the Central Nervous System. International Journal of Molecular Sciences, [online] 19(3), p.833. doi:10.3390/ijms19030833.
  9. Corroon, J. and Phillips, J.A. (2018). A Cross-Sectional Study of Cannabidiol Users. Cannabis and Cannabinoid Research, [online] 3(1), pp.152–161. doi:10.1089/can.2018.0006.
  11. Xiong, W., Cui, T., Cheng, K., Yang, F., Chen, S.-R., Willenbring, D., Guan, Y., Pan, H.-L., Ren, K., Xu, Y. and Zhang, L. (2012). Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors. Journal of Experimental Medicine, [online] 209(6), pp.1121–1134. doi:10.1084/jem.20120242.
  12. Morgan, C.J.A., Das, R.K., Joye, A., Curran, H.V. and Kamboj, S.K. (2013). Cannabidiol reduces cigarette consumption in tobacco smokers: Preliminary findings. Addictive Behaviors, [online] 38(9), pp.2433–2436. doi:10.1016/j.addbeh.2013.03.011.
  13. Oláh, A., Tóth, B.I., Borbíró, I., Sugawara, K., Szöllõsi, A.G., Czifra, G., Pál, B., Ambrus, L., Kloepper, J., Camera, E., Ludovici, M., Picardo, M., Voets, T., Zouboulis, C.C., Paus, R. and Bíró, T. (2014). Cannabidiol exerts sebostatic and antiinflammatory effects on human sebocytes. Journal of Clinical Investigation, [online] 124(9), pp.3713–3724. doi:10.1172/jci64628.
  14. Office (2022). What to Know About Products Containing Cannabis and CBD. [online] U.S. Food and Drug Administration. Available at:
  15. Naik, S., Kolikonda, M., Prabhu, A. and Lippmann, S. (2018). MARIJUANA ON THE BRAIN- A CONCERN. Innovations in clinical neuroscience, [online] 15(1-2), p.12. Available at:
  16. Office (2022). What to Know About Products Containing Cannabis and CBD. [online] U.S. Food and Drug Administration. Available at:


Madison Clarke, MBAHM
MBA in Healthcare Management
She is a professional blog post, article, researcher, and health writer. She has mastered the art of content writing by practicing for years and constantly learning. She is always ready and well equipped to write. It is always a pleasure to bring her skills to use and play her part in helping others achieve their objectives. She has 6 years of experience conducting research in Fitness and health care. She is MBA qualified and has written health content for 8+ years.


Drew is a retired ENT doctor who now lives in the Southeastern US. He was a member of the American Academy of Otolaryngology and a Fellow of the American College of Surgeons. He has a bachelor’s degree in Biology and Psychology and an MD degree. He completed his internship in General Surgery and Residency in Otolaryngology-Head and Neck Surgery and practiced for almost 30 years in all aspects of ENT, including a specialization in disorders of the ear and skull base. Drew is passionate about communicating his clinical experiences and making his knowledge more accessible to the general public by medical writing.

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