Best CBD Oil For Nerve Pain & Neuropathy: Top 7 Brands 2023

Reviewed by Elizabeth Gonzalez Cueto, MD

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Neuropathy pain[1] is mainly characterized by chronic pain, tingling, and numbness. Statistics[2] show that at least one out of ten people in America deal with neuropathic pain. Treating nerve pain using prescribed medication might result in addiction and adverse effects, which might interfere with the patient’s daily lifestyle. People, therefore, seek natural alternatives such as CBD oils for nerve pain. Studies[3] show that CBD oil can be used for pain relief; however, CBD products have no official approval for pain management.

The market is flooded with numerous products claiming to provide the best CBD oils for nerve pain. Since choosing among these products can be overwhelming, we have compiled a list and description of the best and highly reputable companies. These brands have solid reputations for offering top-tier quality CBD products that can reduce neuropathic pain.

Since there are very few regulations on CBD products, some companies might take advantage of this and provide poor-quality products to desperate consumers seeking to reduce nerve pain.

This article will review these brands, their pros and cons, their health benefits, and more about neuropathic pain.

Best CBD Oil for Nerve Pain & Neuropathy 2023

Does CBD Help With Nerve Pain?

Nerve pain medically reviewed journals and articles show that using CBD-infused products[4] can alleviate various symptoms related to neuropathy. These articles and journals show that CBD can be an effective natural alternative for nerve pain. CBD works by slowing pain signals sent to the body by the nerves. CBD stimulates CB1[5] and CB2[6] receptors, therefore, causing an analgesic effect, relieving pain. Also, since autoimmune diseases are among the common causes of nerve pain, CBD reduces inflammation response[7], alleviating nerve pain.

Studies[8] show that CBD boosts nerve cells with anti-inflammatory and antioxidant agents. This implies that CBD protects the nerves from further damage and lets them heal effectively. Also, CBD-infused products can heal nerve damage. CBD is beneficial for reducing chronic pain. This is one of the most preferred natural remedies[9] for treating inflammation and chronic pain.

Top 7 Best CBD Oil For Nerve Pain In 2023

CBDfx CBD + CBG Oil Wellness Tincture

Cbdfx offers some of the best quality CBD oils in the market. This reputable company offers high-potency CBD products that contain full-spectrum CBD oil with pain management properties.

  • Full-spectrum CBD oil
  • A vast range of products
  • Multiple potencies
  • Vegan friendly
  • Third-party tested
  • 60-day money-back guarantee
  • Expensive CBD products
  • Contains THC

This brand offers top-notch CBD products infused with full-spectrum CBD oils. This product has all-natural ingredients that have antioxidant and anti-inflammatory properties. Ingredients such as Coenzyme Q10[10] and curcumin can help with neuropathic pain by combating inflammation and alleviating damage from free radicals. This full-spectrum CBD oil contains all the chemical compounds from cannabis plants, including CBG. This compound can kill bacteria[11], alleviate inflammation[12], and contains neuroprotective[13] agents. Also, as one of the most effective hemp-derived CBD products, this oil contains proprietary terpene formula and other cannabinoids that are essential in pain relief; they offer the entourage effect[14], which can be beneficial in dealing with nerve pain.

Joy Organics

Joy Organics CBD Oil

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This is one of the most preferred brands among CBD users, especially those that prefer broad-spectrum CBD. Joy Organics offers top-tier quality products that contain all-natural ingredients.

  • All organic ingredients
  • THC free
  • Free shipping
  • Certified Non-GMO
  • Relatively pricey
  • Offers domestic shipping only

This family-owned business designed stellar quality products that can be beneficial in treating nerve damage. The brand offers broad spectrum oils that come in CBD tinctures, salves, gummies, soft gels, pet products, and many more. Joy Organics uses high tech to manufacture CBD products. For instance. the brand uses nanoemulsion technology to enhance bioavailability. This implies that the absorption and bioavailability of these soft gels are highly enhanced and quickly absorbed into the body for fast nerve damage relief. Also, these products come with a ninety-day money-back guarantee and are third-party tested to guarantee efficacy, purity, and safety.

Spruce CBD

Spruce Cbd

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This brand offers stellar quality  CBD oil products with high potency and undergoes third-party testing. Spruce CBD oil is obtained through novel moonshine methods of extraction and comes in multiple potencies.

  • Publishes third-party testing lab results
  • High potency
  • Multiple strengths
  • Uses the Novel moonshine method of extraction
  • Low THC level
  • Pricey
  • Limited range of products

This brand has a solid reputation in the CBD industry despite being new. Spruce CBD is dedicated to offering top-tier quality CBD products for pain relief, therefore beneficial for nerve pain. This family-owned company source hemp from North Carolina and Kentucky; some of the best and most highly reputable organic hemp farmers. The CBD oil is obtained through the moonshine method of extraction, which offers stellar quality CBD oils containing low terpenes and THC levels. Users report how effective this product is for nerve pain, and it comes in multiple potencies that range from 80 mg to 2400 mg of CBD oil in each serving. This brand offers full-spectrum CBD products which can effectively alleviate neuropathic pain. However, if you are sensitive to THC, these products might not be suitable.

Savage CBD

Savage CBD

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This company offers high-quality products that contain all-organic hemp oil. These products are third-party tested and come with free shipping.

  • Free shipping
  • Third-party tested
  • Published lab results
  • Moderately prices and great value
  • No money-back guarantee

Savage CBD offers premium quality products that contain organically farmed hemp. The company is based in California and offers third-party-tested products containing CBD’s purest form, CBD isolates. It also offers full spectrum products such as gummies, capsules, and tinctures. The brand prioritizes transparency; therefore, each batch has readily available lab results that users can access. Although the brand has no return policy, CBD users love these products as they offer various bodily benefits.


koi Cbd

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This brand offers high-quality products that are THC free. These products contain all-organic ingredients, and the brand prioritizes transparency.

  • Third-party tested
  • Uses USA-grown hemp
  • THC free products
  • 30-day money-back guarantee
  • Some products have no COA
  • Unclear method of extraction

This brand is dedicated to providing premium quality products, not only for pain but to improve the overall health and wellness of the user. These products contain US-farmed hemp and do not contain THC. The brand’s products undergo third-party testing to guarantee effectiveness, purity, and safety. Koi CBD offers a variety of products, such as edibles, oils, vape juices, skincare products, and many more. These products come in multiple flavors; therefore, users have an opportunity to choose their preferred taste. The brand also claims that these products do not contain any artificial additives, fillers, or flavorings.

CBD Pure

CBDPure Oil

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This company is among the top-rated brands. It offers top-tier quality products containing all-organic ingredients and is third-party tested to ensure efficacy and purity.

  • Accessible laboratory results
  • No artificial flavors or additives
  • Free shipping
  • All-organic ingredients
  • Limited range of products

This company lives up to its anime and offers some of the best and top-rated products. These products are designed to boost the users’ overall health and wellness, therefore beneficial in reducing inflammation. These CBD oil products come in various types, including CBD isolate, full spectrum, and broad spectrum CBD oil. You can choose CBD isolate products if you wish to enjoy CBD in its purest form. Full spectrum contains all the chemical compounds in cannabis plants. It is an excellent option to alleviate nerve pain while experiencing the entourage effects of these cannabinoids. Broad-spectrum CBD products are excellent options for anyone seeking to enjoy CBD oil without THC. The brand uses organic hemp from Colorado, and all products are manufactured under GMP-approved standards. This is one of the most transparent companies since all lab results can be accessed on the brand’s website.

Royal CBD


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If you prefer the natural taste of CBD oil, then Royal CBD is an excellent option. This company offers unflavored full-spectrum CBD oil that comes in high potency, therefore, is highly effective for nerve pain.

  • No artificial flavors or additives
  • Full-spectrum CBD oil
  • Multiple potencies
  • Simple website
  • Third-party tested
  • Limited range of CBD products
  • No lab reports on the website

This brand offers some of the most effective CBD products to deal with chronic inflammation and other health issues. The brand offers a variety of products that come in various forms, such as oral CBD and topical CBD. These products contain full-spectrum hemp oil, and reviews indicate how effective they are in improving the overall health and wellness of the body. Royal CBD has a very straightforward website design and is dedicated to offering high-potency CBD oils, topicals, capsules, gummies, and pet products. Although the brand claims all its CBD products undergo third-party lab testing, there are no available results to support this claim. Royal CBD is an excellent choice if you are looking to alleviate nerve pain while enjoying the natural taste of CBD; the products have no synthetic additives or flavors.

What Is Neuropathy?

When the body experiences nerve damage, it malfunctions; this condition is called neuropathy. The nervous system is categorized into two, including the peripheral nervous system and the central nervous system. The latter consists of the brain and spinal cord, while the former comprises the nerves that lead to the spinal cord and the brain. The Central nervous system receives signals from the peripheral nervous system, which makes the body detect feelings such as pain and temperature. Neuropathic pain[15] makes the nerves send signals such as constant pain, tingling, and numbness.

What Causes Neuropathic Pain?

Various nerve pain research does not conclude on a specific cause of nerve damage pain; however, there are various causes of neuropathic pain, they include:

  • Diabetes: Diabetic neuropathy is among the common symptoms of diabetes. Also, diabetic neuropathy is typically featured by nerve pain in the feet and hands.
  • Trauma and nerve injury: nerve injuries can result in pain and inflammation.
  • Infectious or Inflammatory ailments such as hepatitis, HIV, shingles, Guillain-Barre, lupus, and arthritis can cause inflammation by affecting the autoimmune system.
  • Medication and diet[16]: there are particular medications, poor nutrition, or exposure to harmful chemicals such as mercury which can affect the nervous system.

How We Choose The Best CBD For Nerve Pain?

There are various factors to consider when choosing the best CBD oils for dealing with neuropathy. They include:

  • CBD type: CBD can be categorized into CBD isolates, full spectrum, and broad spectrum. You can choose according to the desired results and the body’s tolerance to CBD.
  • Product type: CBD-infused products come in different forms, including CBD creams, gummies, capsules, tinctures, and many more.
  • Potency: these products come in multiple potencies, high, moderate, and low. You can begin with a low dosage and then increase it gradually as you monitor your body.
  • Third-party testing: avoid brands without independent lab testing results. There you are, buying a CBD cream, gummy, oil, topical, vape juice, and many more; always check for safety and efficacy reasons. Also, confirm if the COA included what the brand is marketing.
  • Other factors are customer reviews, brand reputation, pricing, ingredients, hemp source, and many more.

Health Benefits

CBD-infused products provide a variety of benefits to the body apart from treating nerve-related symptoms. They include:

  • Reducing anxiety and depression
  • Reducing PTSD symptoms
  • Reducing seizures
  • Treating opioid addiction
  • Easing diabetic complications
  • Pain management
  • Neuroprotective properties
  • Boost cardiovascular health

Potential Side Effects

Many users tolerate the consumption of CBD; however, it has some side effects. Some users report drowsiness, diarrhea, dry mouth, fatigue, appetite, and weight change. These products might result in sedation when mixed with alcohol or other recreational drugs. It can also interact with prescribed medication; therefore, if you have any underlying condition, always consult a healthcare professional before using these drugs.


CBD dosage for neuropathy depends on various factors such as body weight, body tolerance levels, type of product, and condition being treated. It is vital to consult a healthcare professional about the condition you seek to treat; they can help you determine an effective dosage. Always follow the manufacturer’s instructions when taking these products. This will help you reap prominent results and avoid adverse health effects.

Frequently Asked Questions (FAQs)

Are there any side effects?

Some users report reduced appetite and weight, fatigue, drowsiness, dry mouth, and diarrhea.

Will I get high?

These products do not contain psychoactive properties.

How long till I see results?

This depends on the type of product in question.

Does the FDA approve them?

The only FDA-approved CBD product is epidiolex, and it’s used to treat seizures.

What benefits does CBD offer?

CBD can reduce anxiety, pain, and inflammation, boost heart health, and reduce seizures.

Where can I buy CBD?

These products are available on the product’s official website. Also, you can find them on other online platforms such as Amazon; however, the best place is the company’s website.

Is CBD legal?

These products are federally legal; however, they’re forbidden in certain states. Herefore, always check the local state’s laws when traveling.

Do I need a prescription?

These products do not require a medical prescription; however, you can consult your doctor before using them.

+ 16 sources

MIDSS adheres to strict procurement guidelines and relies on peer-reviewed studies, academic research institutes, and medical associations. We work mainly with peer-reviewed studies to ensure the accuracy of the information. We avoid the use of tertiary references. You can read about how we ensure the accuracy and timeliness of our content in our editorial process.

  1. Mayo Clinic. “Peripheral Neuropathy – Symptoms and Causes.” Mayo Clinic, 2019,
  2. DiBonaventura, Marco, et al. “The Prevalence of Probable Neuropathic Pain in the US: Results from a Multimodal General-Population Health Survey.” Journal of Pain Research, vol. Volume 10, Nov. 2017, pp. 2525–2538,, 10.2147/jpr.s127014.
  3. Argueta, Donovan A., et al. “A Balanced Approach for Cannabidiol Use in Chronic Pain.” Frontiers in Pharmacology, vol. 11, 30 Apr. 2020,, 10.3389/fphar.2020.00561.
  4. Quintero, Jose-Manuel, et al. A Systematic Review on Cannabinoids for Neuropathic Pain Administered by Routes Other than Oral or Inhalation. 20 May 2022.
  5. Navarro, Gemma, et al. “Cannabigerol Action at Cannabinoid CB1 and CB2 Receptors and at CB1–CB2 Heteroreceptor Complexes.” Frontiers in Pharmacology, vol. 9, 21 June 2018, 10.3389/fphar.2018.00632.
  6. Navarro, Gemma, et al. “Cannabigerol Action at Cannabinoid CB1 and CB2 Receptors and at CB1–CB2 Heteroreceptor Complexes.” Frontiers in Pharmacology, vol. 9, 21 June 2018, 10.3389/fphar.2018.00632.
  7. Vučković, Sonja, et al. “Cannabinoids and Pain: New Insights from Old Molecules.” Frontiers in Pharmacology, vol. 9, 13 Nov. 2018,, 10.3389/fphar.2018.01259.
  8. Campos, Alline C, et al. “Cannabidiol, Neuroprotection and Neuropsychiatric Disorders.” Pharmacological Research, vol. 112, 2016, pp. 119–127,, 10.1016/j.phrs.2016.01.033. Accessed 17 Nov. 2019.
  9. Lynch, M. E., and Mark A. Ware. “Cannabinoids for the Treatment of Chronic Non-Cancer Pain: An Updated Systematic Review of Randomized Controlled Trials.” Journal of Neuroimmune Pharmacology, vol. 10, no. 2, 22 Mar. 2015, pp. 293–301, 10.1007/s11481-015-9600-6.
  10. Saini, Rajiv. “Coenzyme Q10: The Essential Nutrient.” Journal of Pharmacy and Bioallied Sciences, vol. 3, no. 3, 2011, p. 466, 10.4103/0975-7406.84471.
  11. Appendino, Giovanni, et al. “Antibacterial Cannabinoids FromCannabis Sativa: A Structure−Activity Study.” Journal of Natural Products, vol. 71, no. 8, Aug. 2008, pp. 1427–1430, 10.1021/np8002673.
  12. Borrelli, Francesca, et al. “Beneficial Effect of the Non-Psychotropic Plant Cannabinoid Cannabigerol on Experimental Inflammatory Bowel Disease.” Biochemical Pharmacology, vol. 85, no. 9, 1 May 2013, pp. 1306–1316,, 10.1016/j.bcp.2013.01.017.
  13. Valdeolivas, Sara, et al. “Neuroprotective Properties of Cannabigerol in Huntington’s Disease: Studies in R6/2 Mice and 3-Nitropropionate-Lesioned Mice.” Neurotherapeutics, vol. 12, no. 1, 25 Sept. 2014, pp. 185–199, 10.1007/s13311-014-0304-z.
  14. Ferber, Sari Goldstein, et al. “The “Entourage Effect”: Terpenes Coupled with Cannabinoids for the Treatment of Mood Disorders and Anxiety Disorders.” Current Neuropharmacology, vol. 18, no. 2, 23 Jan. 2020, pp. 87–96, 10.2174/1570159×17666190903103923.
  15. “Peripheral Neuropathy: What It Is, Symptoms & Treatment.” Cleveland Clinic,
  16. “Peripheral Neuropathy: What It Is, Symptoms & Treatment.” Cleveland Clinic,


Madison Clarke, MBAHM
MBA in Healthcare Management
She is a professional blog post, article, researcher, and health writer. She has mastered the art of content writing by practicing for years and constantly learning. She is always ready and well equipped to write. It is always a pleasure to bring her skills to use and play her part in helping others achieve their objectives. She has 6 years of experience conducting research in Fitness and health care. She is MBA qualified and has written health content for 8+ years.


Elizabeth Gonzalez Cueto, MD
Medical Doctor & Medical Writer
My name is Elizabeth and I am a Medical Doctor (MBBS) with experience as a medical and research article writer, reviewer and proofreader. I have worked for the American Journal of Case Reports, the Medical Science Monitor, and Pacific Medical Training as a medical article reviewer and writer. Besides, I have worked as a medical interpreter and translator for Angel City research and SC3 Research group as a medical research assistant for several clinical trials. My academic background includes many international scientific environments like Oxford University, United Kingdom. Hannover Medical School, the University of Tours, France. the Autonomous University of Barcelona and the National Polytechnic Institute in Mexico.

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