8 Best Anti-Aging Supplements For Fine Lines & Wrinkles

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Reviewed by Elizabeth Gonzalez Cueto, MD

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Thorne Research Meriva SF
NOW Foods Green Tea Extract
Persona Vital Proteins Collagen Peptides
Product Thorne Research Meriva SF NOW Foods Green Tea Extract Persona Vital Proteins Collagen Peptides
Rating 4.5 stars 4.5 stars 4.0 stars
Pros
  • Gluten-free, soy-free, and allergen-free formula with increased absorption in the body.
  • Fight free radicals, antioxidants, and anti-aging properties
  • Easily digested and can be dissolved in hot and cold beverages
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Aging [1] is a complex biological phenomenon attributed to endogenous and exogenous factors including genetics, ionizing radiation, chemicals, chronic sun exposure, hormones, metabolic processes, and toxins. These factors work together to cause physiological and anatomical alterations in the skin layers and skin appearance. Loss of skin elasticity gives rise to the sagging of skin. The slower rate of wound healing is also associated with the aging process.

Anti-aging supplements[2], in addition to other anti-aging measures, have been developed to slow or reverse skin damage during the onset of skin aging. Hormone supplements including estrogen, progestins, and vitamin D are useful for slowing or reversing the onset of aging. In addition to hormonal supplements, collagen supplements[3] slow down the aging process and improve the appearance of wrinkles. Collagen supplements support skin hydration and improve skin elasticity. They maintain the strength, structure, and stability of the dermal layers of the skin. Collagen supplements enhance the mechanical properties of the skin and demonstrate antioxidant properties.

8 Best Anti-Aging Supplements In 2022

Features Of The Best Anti-Aging Supplements – Thorne Research Meriva SF

Thorn Research Meriva – 500 SF is a soy-free, gluten-free, and dairy-free anti-aging supplement with a key anti-aging ingredient, curcumin. Each supplement capsule comprises 500 mg curcumin phytosome. The supplements are free of eggs, tree nuts, peanuts, and other major allergens. Lower quantities of the supplement are required owing to the increased potency of the anti-aging supplements. The sustained release and well-absorbed curcumin formula have anti-inflammatory properties. The supplement supports healthy aging and inflammatory responses in the body. 

Curcumin phytosome has better absorption as compared to other curcumin extracts and has antioxidant properties. A study demonstrated that curcumin phytosome has 29 times higher absorption as compared to ordinary curcumin extracts. The phytosome technology used in the production of Thorn Research Meriva – 500 SF facilitates the attachment of phospholipid and curcumin extract. This attachment is responsible for the increased absorption of curcumin in the body.

Thorne Research Meriva SF
Thorne Research Meriva SF
  • Gluten-free, soy-free, and allergen-free formula
  • Increased potency
  • Increased absorption
NOW Foods Green Tea Extract
NOW Foods Green Tea Extract
  • Scavenge free radicals
  • Antioxidant properties
  • A normal response to metabolic stress
Persona Vital Proteins Collagen Peptides
Persona Vital Proteins Collagen Peptides
  • Easily digested
  • Can be dissolved in hot or cold liquids
  • Improves the hair, nail, and skin health
  • Promotes collagen production
Qunol Ultra CoQ10
Qunol Ultra CoQ10
  • Powerful antioxidant
  • Increased absorption than regular CoQ10
  • Fat-soluble and water-soluble supplement
Renue by Science Citrus Sublingual Powder
Renue by Science Citrus Sublingual Powder
  • Gluten-free and vegan-friendly formula
  • Third-party lab testing to ensure the purity and safety of the product
  • The sublingual mode of delivery ensures faster absorption
Life Extension Optimized Saffron
Life Extension Optimized Saffron
  • Vegetarian
  • Healthy weight management
  • Healthy appetite management

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New Customers Get $5 Off $50: VITAMIN5

Nature’s Bounty Vitamin C
Nature’s Bounty Vitamin C
  • Combat oxidative stress
  • Improve the function of the immune system
  • Small-sized capsules are easier to swallow
Nordic Naturals Vitamin E Complex
Nordic Naturals Vitamin E Complex
  • Maintains cellular health
  • Highly absorbable formulation
  • Healthy immune response

8 Best Anti-Aging Supplements For Fine Lines & Wrinkles

Thorne Research Meriva SF

Thorne Research Minerva – SF 500 is an anti-inflammatory anti-aging supplement made of curcumin phytosome, which has increased absorption and potency.

  • Increased bioavailability
  • Increased potency
  • Gluten-free supplement
  • Increased rate of absorption
  • Higher price than standard anti-aging supplements

Thorne Research Minerva – SF 500 is a soy-free, gluten-free, allergen-free, and dairy-free curcumin formula, which has increased absorption and potency as compared to other curcumin extracts. Increased absorption of these supplements is attributed to the attachment of phospholipid and curcumin extract. The increased potency of these supplements leads to decreased levels of curcumin required in the supplements. Even a smaller amount of curcumin phytosome supplement is sufficient for increased concentration of curcumin in the blood plasma.

Individuals who use these supplements report an improvement in the symptoms including breathing difficulties, soreness, fatigue, weight alterations, sinus problems, muscle discomfort, and heartburn. Many users report that smaller quantities of the capsules are required for producing these anti-inflammatory effects. The curcumin phytosome supplements promote recovery and healing of the skin while alleviating fatigue, discomfort, and soreness.

NOW Foods Green Tea Extract

NOW Foods Green Tea Extract comprises an activated formula of green tea. The green tea extract supplements contain catechins and polyphenols, which have impressive health benefits.

  • Improves cellular health
  • Potent scavenger of free radicals
  • Antioxidant properties
  • Maintains healthy response of the body to metabolic stress
  • Mild sickness in some users

The NOW Foods Green Tea Extract supplement is a potent scavenger of free radicals and has the antioxidant power of ascorbic acid or vitamin C, part of anti-aging vitamins. It facilitates the consumption of active components of green tea extract as a concentrated formula. The green tea extract supplement contains bioactive compounds such as catechins and polyphenols. These compounds scavenge and neutralize the free radicals as well as help the body generate a normal and healthy response to metabolic stress, hence, supporting healthy aging of the skin.

The green tea extract supplements curb hunger and mediate weight loss in supplement users. It also promotes increased energy levels in the users and facilitates healing and recovery of the body. The users report being awake, active, and high on energy levels throughout the day. According to the users, the supplements are affordable and efficient. The pills can be swallowed easily and compensate for excessive consumption of green tea.

Persona Vital Proteins Collagen Peptides

The Persona Vital Proteins Collagen Peptides is a bioavailable collagen peptides powder, which is easily absorbed and digested by the body.

  • Easily digested
  • Can be dissolved in hot or cold liquids
  • Improves the hair, nail, and skin health
  • The Original Persona Vital Proteins Collagen Peptides is unflavored

The Persona Vital Proteins Collagen Peptides are composed of original collagen peptides, vitamin C, and hyaluronic acid. Its ingredients promote the health of nails, bones, ligaments, joints, hair, tendons, and skin. These supplements are easy to use and can be dissolved in hot and cold beverages. The supplement can also be added to foods for easy consumption. This supplement is important for athletes and people who frequently engage in physical activities, as it supports the recovery and healing of joint injuries.

The product does not contain any added sugars, gluten, and dairy, therefore, suitable for individuals who are allergic to these ingredients. Vitamin C in supplements strengthens the function of the immune system and increases collagen production. Hyaluronic acid promotes hydration of the aging skin and provides a glowing skin complexion.

Reports say that the product dissolves instantaneously in cold and hot beverages. The users report improvement in pain and body aches. The collagen supplement improves the appearance of hair and nails and has become an essential addition to the antiaging regimen of the users. A major concern among the users is the higher price of the product.

Qunol Ultra CoQ10

The nutritional supplement is soluble in both fat and water, therefore, this dietary supplement is efficiently absorbed into the body.

  • Powerful antioxidant
  • Increased absorption than regular CoQ10
  • Fat-soluble and water-soluble supplements
  • Maintain the health of the cardiovascular system
  • Potential allergic reactions to the ingredients

Individuals who use statins for lowering blood cholesterol are also subjected to a lowering in the levels of CoQ10. Intake of Qunol Ultra CoQ10 with statin therapy restores the levels of CoQ10 in the body. CoQ10 depletion may also occur in older individuals and individuals exposed to stress. It is a powerful antioxidant, which protects skin against free radicals and prevents damage to healthy skin cells. CoQ10 supports the production of energy, supports vascular health, and promotes normal levels of blood pressure.

Qunol Ultra CoQ10 is a supplement, which replenishes the levels of CoQ10 in the body. The product is free of dairy products, poultry products, shellfish, peanuts, gluten, tree nuts, yeast, and wheat. According to the users, the product is recommended by cardiologists for supporting cardiovascular health. The supplement improves the energy levels as well as the appearance of the skin. The users also report relief from cramps after using the supplement.

Renue by Science Citrus Sublingual Powder

Renue by Science Citrus Sublingual Powder is a fast-dissolvable formulation, which is delivered in the body via a sublingual route, attributing to faster absorption and higher bioavailability of the product.

  • cGMP certified and non-GMO
  • Gluten-free and vegan-friendly formula
  • Third-party lab testing to ensure the purity and safety of the product
  • The sublingual mode of delivery ensures faster absorption
  • Poor return policy

Renue by Science Citrus Sublingual Powder comprises beta-nicotinamide mononucleotide, which serves as a precursor for the production of nicotinamide adenine dinucleotide (NAD). This dietary supplement is manufactured at an FDA-approved facility. Sublingual delivery of the supplement causes NAD to bypass the liver metabolism partially and produces anti-aging effects in the body. Smaller quantities of the supplement are beneficial for producing positive effects in the body. The sublingual citrus powder has far better absorption than supplement capsules.

According to the users, the product improves energy levels, strengthens the immune system, and accelerates the recovery of the body. This supplement is also useful for maintaining the health of skin and hair. Users report that the supplement improves skin texture and appearance. The supplement also improves the quality of sleep and mood. One of the users suffering from retinitis pigmentosa reported improvement in vision after using the sublingual supplement.

Life Extension Optimized Saffron

Life Extension Optimized Saffron

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New Customers Get $5 Off $50: VITAMIN5

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Life Extension Optimized Saffron contains optimized saffron, which facilitates healthy management of weight and appetite as well as mediates the neurotransmitters to reduce the habit of snacking.

  • Non-GMO
  • Vegetarian
  • Healthy weight management
  • Healthy appetite management
  • Some individuals are allergic to the ingredients including saffron

Saffron has many health benefits. Research suggests that optimized saffron, which is a saffron stigma extract, is useful for reducing snacking between meals and during the night. They also help with the reduction of stress eating. It is recommended that the optimized saffron supplements shall be obtained in a combination with regular exercise and a healthy and balanced diet. This saffron stigma extract does not contain caffeine and has been clinically tested for improving satiety in users. Life Extension Optimized Saffron also influences the neurotransmitters for resisting the urge to snack and modulate the appetite.

Users report the supplements to be useful for controlling sugar cravings, reducing weight, and improving mood. They also report being more relaxed after persistent use of these supplements and also observed improvement in the quality and duration of sleep.

Nature’s Bounty Vitamin C

The Nature’s Bounty Vitamin C is enriched with vitamin C, responsible for combating oxidative stress by fighting off the free radicals. Nature’s Bounty also offers vitamin C supplements with zinc, an essential trace mineral.

  • Combat oxidative stress
  • Improve the function of the immune system
  • Small-sized capsules are easier to swallow
  • Increased duration to demonstrate results

Free radicals induce oxidative stress in the cells and may lead to premature aging of the skin. The gluten-free, preservative-free, and sodium-free formulation of the vitamin supplements make these safe for consumers. Vitamin C also facilitates the functioning of the white blood cells, hence, strengthening the immune system of the body.

Nature’s Bounty also offers vitamin D supplements for improved function of the skeletal and immune system of the body as well as promotes overall health and wellbeing. The users have reported improvement in immunity and occurrence of healthy changes in their lives.

Nordic Naturals Vitamin E Complex

The vitamin E complex is a blend of six forms of vitamin E which protect the cells from free radicals.

  • Combination of six forms of vitamin E to provide antioxidant support
  • Maintains cellular health
  • Highly absorbable formulation
  • Healthy immune response
  • Relatively less dosage

The antioxidant formulation of Nordic Naturals Vitamin E Complex neutralizes the free radicals while maintaining the health and metabolism of the cells. An optimal ratio of tocotrienols and alpha-tocopherol are present in the vitamin E complex, for the optimal bioavailability of the supplement in the body. Vitamin E complex also promotes the function of the immune system and supports a healthy response of the immune system against pathogens. Users consume the supplements on daily basis and acknowledge the quality of the product.

Common Aging Signs

Common anti-aging supplements include collagen supplements, green tea extract supplements, curcumin phytosome supplements, nicotinamide mononucleotide supplements, vitamin E supplements, vitamin C supplements, and optimized saffron supplements.

Do Anti-Aging Supplements Work At All? 

Anti-aging supplements replenish the skin and restore the levels of nutrients and precursors for substances integral to the function and structure of the skin. These anti-aging supplements also boost energy levels, improve the functioning of the immune system, mediate the mood, suppress cravings for snacks between meals, prevent premature aging, and promote overall well-being. Women with underlying health conditions such as hypercholesterolemia may consume statin with CoQ10 supplements to replenish the levels of this coenzyme in the body.

How Could Anti-Aging Supplements Benefit Women?

Curcumin, CoQ10, collagen, vitamin C, nicotinamide mononucleotide, collagen, and vitamin E are important supplements that replenish the levels of these substances in the body. The anti-aging supplements benefit women in particular, such that these supplements improve skin hydration, and skin tone, and manage aging-related diseases of the skin and body including visible signs of aging, arthritis, and cardiovascular diseases. The vitamin C supplements mediate the body’s natural collagen production, hence, improving the visible signs of aging such as fine lines and wrinkles.

How To Use Anti-Aging Supplements Effectively

The anti-aging supplements shall be used according to the instructions given in the product description. These supplements can be used in combination with a healthy and balanced diet and increased physical activity, for the management of skin aging and age-related diseases.

Importance of Vitamin C for Skin Health and Healthy Aging

Supplementation of vitamin C facilitates the body’s natural production of collagen[4], from amino acids[5] including glycine, proline, and hydroxyproline. Every third position in the protein structure is acquired by amino acid glycine. The body naturally produces collagen, which promotes skin health, maintains normal wound healing, and facilitates healthy aging. Vitamin C supplements protect the cells from oxidative stress and promote longevity. It also maintains the integrity of the cell membranes[6]. In addition to skin aging, vitamin C also slows down the onset of brain aging by reducing oxidative stress, decreasing cognitive decline, and improving mental health.

Frequently Asked Questions (FAQs)

Which vitamin is best for anti-aging?

Vitamin E and vitamin C are important anti-aging vitamins.

What should you look for when buying anti-aging supplements?

One shall consider the composition, dosage, potential adverse effects, treatment goals, and price range when buying anti-aging supplements.

What supplements make you look younger?

Supplements that promote collagen production tend to improve the visible signs of aging and provide a younger appearance.

How to use anti-aging supplements?

Follow the instructions provided by the supplements’ manufacturer, given in the product description.

How does optimized saffron facilitate weight and appetite management?

Optimized saffron modulates the neurotransmitters to control cravings and help manage weight and appetite.

Is sublingual mode of delivery better than oral capsules?

Sublingual supplements are absorbed faster into the bloodstream and have greater bioavailability than oral capsules?

Which supplements are both fat and water-soluble?

Qunol Ultra CoQ10 supplement is both fat and water-soluble.

Can vitamin C slow the onset of brain aging?

Vitamin C supplements protect the cells from oxidative damage by free radicals and reduce cognitive decline.

+ 13 sources

MIDSS has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. We work mostly with peer-reviewed studies to ensure accurate information. We avoid using tertiary references. You can learn more about how we ensure our content is accurate and current by reading our editorial policy.

  1. Ganceviciene, R., Liakou, A.I., Theodoridis, A., Makrantonaki, E. and Zouboulis, C.C. (2012). Skin anti-aging strategies. Dermato-Endocrinology, [online] 4(3), pp.308–319. doi:10.4161/derm.22804.
  2. Son, D.-H., Park, W.-J. and Lee, Y.-J. (2019). Recent Advances in Anti-Aging Medicine. Korean Journal of Family Medicine, [online] 40(5), pp.289–296. doi:10.4082/kjfm.19.0087.
  3. Al-Atif, H. (2022). Collagen Supplements for Aging and Wrinkles: A Paradigm Shift in the Field of Dermatology and Cosmetics. Dermatology Practical & Conceptual, [online] p.e2022018. doi:10.5826/dpc.1201a18.
  4. DePhillipo, N.N., Aman, Z.S., Kennedy, M.I., Begley, J.P., Moatshe, G. and LaPrade, R.F. (2018). Efficacy of Vitamin C Supplementation on Collagen Synthesis and Oxidative Stress After Musculoskeletal Injuries: A Systematic Review. Orthopaedic Journal of Sports Medicine, [online] 6(10), p.232596711880454. doi:10.1177/2325967118804544.
  5. Wu, M., Cronin, K. and Crane, J.S. (2021). Biochemistry, Collagen Synthesis. [online] Nih.gov. Available at: https://www.ncbi.nlm.nih.gov/books/NBK507709/ [Accessed 20 Jul. 2022].
  6. May, J.M. (1999). Is ascorbic acid an antioxidant for the plasma membrane? The FASEB Journal, [online] 13(9), pp.995–1006. doi:10.1096/fasebj.13.9.995.
  7. Ganceviciene, R., Liakou, A. I., Theodoridis, A., Makrantonaki, E., & Zouboulis, C. C. (2012). Skin anti-aging strategies. Dermato-endocrinology, 4(3), 308–319. https://doi.org/10.4161/derm.22804
  8. Son, D. H., Park, W. J., & Lee, Y. J. (2019). Recent Advances in Anti-Aging Medicine. Korean journal of family medicine, 40(5), 289–296. https://doi.org/10.4082/kjfm.19.0087
  9. Al-Atif H. (2022). Collagen Supplements for Aging and Wrinkles: A Paradigm Shift in the Fields of Dermatology and Cosmetics. Dermatology practical & conceptual, 12(1), e2022018. https://doi.org/10.5826/dpc.1201a18
  10. DePhillipo, N. N., Aman, Z. S., Kennedy, M. I., Begley, J. P., Moatshe, G., & LaPrade, R. F. (2018). Efficacy of Vitamin C Supplementation on Collagen Synthesis and Oxidative Stress After Musculoskeletal Injuries: A Systematic Review. Orthopaedic journal of sports medicine, 6(10), 2325967118804544. https://doi.org/10.1177/2325967118804544
  11. Wu M, Cronin K, Crane JS. Biochemistry, Collagen Synthesis. [Updated 2021 Sep 13]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK507709/
  12. May J. M. (1999). Is ascorbic acid an antioxidant for the plasma membrane?. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 13(9), 995–1006. https://doi.org/10.1096/fasebj.13.9.995
  13. Mock, J. T., Chaudhari, K., Sidhu, A., & Sumien, N. (2017). The influence of vitamins E and C and exercise on brain aging. Experimental gerontology, 94, 69–72. https://doi.org/10.1016/j.exger.2016.12.008

ABOUT THE AUTHOR

Rick Bayer, MD
Medical Writer & Medical Doctor
Rick is a Final Year Medical Student. Passionate about medicine, fitness and personal growth, he is always ready to challenge himself to accomplish tasks and especially spread correct medical information to people. Rick is a long-term medical writer for several sites. With more than 5 years of experience in medical writing, he has completed 200+ projects with private and business clients.

ABOUT MEDICAL REVIEWER

Elizabeth Gonzalez Cueto, MD
Medical Doctor & Medical Writer
Dedicated medical doctors and masters are in science with experience in infectious diseases. Medical article writer and reviewer. Trained in BSL-2 and BSL-3 environments, with a particular interest in virology, immunology, vaccinology, and clinical trials